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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity

Relating the macroscopic properties of protein-based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of de novo protein building blocks, as well as the interaction dynamics between...

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Detalles Bibliográficos
Autores principales: Mout, Rubul, Bretherton, Ross C., Decarreau, Justin, Lee, Sangmin, Edman, Natasha I., Ahlrichs, Maggie, Hsia, Yang, Sahtoe, Danny D., Ueda, George, Gregorio, Nicole, Sharma, Alee, Schulman, Rebecca, DeForest, Cole A., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312586/
https://www.ncbi.nlm.nih.gov/pubmed/37398067
http://dx.doi.org/10.1101/2023.06.02.543449