Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting

We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5 Å, 2.8 Å, and 2.9Å. These structures, all obtained at nominally zero membrane potential in detergent micelles,...

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Detalles Bibliográficos
Autores principales: Wu, Yangyu, Yan, Yangyang, Yang, Youshan, Bian, Shumin, Rivetta, Alberto, Allen, Ken, Sigworth, Fred J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312591/
https://www.ncbi.nlm.nih.gov/pubmed/37398110
http://dx.doi.org/10.1101/2023.06.02.543446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312591/
https://www.ncbi.nlm.nih.gov/pubmed/37398110
http://dx.doi.org/10.1101/2023.06.02.543446

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