Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly

The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory disorders. However, the activation and regulation of NLRP3 inflammasome signal...

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Detalles Bibliográficos
Autores principales: Stanton, Caroline, Sun, Jie, Nutsch, Kayla, Rosarda, Jessica D., Nguyen, Thu, Li-Ma, Chloris, Kutseikin, Sergei, Saez, Enrique, Teijaro, John R., Wiseman, R. Luke, Bollong, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312593/
https://www.ncbi.nlm.nih.gov/pubmed/37398499
http://dx.doi.org/10.1101/2023.06.01.543248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312593/
https://www.ncbi.nlm.nih.gov/pubmed/37398499
http://dx.doi.org/10.1101/2023.06.01.543248

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