Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme

Enzymes catalyze biochemical reactions through precise positioning of substrates, cofactors, and amino acids to modulate the transition-state free energy. However, the role of conformational dynamics remains poorly understood due to lack of experimental access. This shortcoming is evident with E. co...

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Detalles Bibliográficos
Autores principales: Greisman, Jack B., Dalton, Kevin M., Brookner, Dennis E., Klureza, Margaret A., Sheehan, Candice J., Kim, In-Sik, Henning, Robert W., Russi, Silvia, Hekstra, Doeke R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312612/
https://www.ncbi.nlm.nih.gov/pubmed/37398233
http://dx.doi.org/10.1101/2023.06.02.543507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312612/
https://www.ncbi.nlm.nih.gov/pubmed/37398233
http://dx.doi.org/10.1101/2023.06.02.543507

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