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Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme

Enzymes catalyze biochemical reactions through precise positioning of substrates, cofactors, and amino acids to modulate the transition-state free energy. However, the role of conformational dynamics remains poorly understood due to lack of experimental access. This shortcoming is evident with E. co...

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Detalles Bibliográficos
Autores principales:	Greisman, Jack B., Dalton, Kevin M., Brookner, Dennis E., Klureza, Margaret A., Sheehan, Candice J., Kim, In-Sik, Henning, Robert W., Russi, Silvia, Hekstra, Doeke R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312612/ https://www.ncbi.nlm.nih.gov/pubmed/37398233 http://dx.doi.org/10.1101/2023.06.02.543507

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