Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease loci

We introduce CoRE-BED, a framework trained using 19 epigenomic features encompassing 33 major cell and tissue types to predict cell-type-specific regulatory function. CoRE-BED’s interpretability facilitates causal inference and functional prioritization. CoRE-BED identifies nine functional classes d...

Descripción completa

Detalles Bibliográficos
Autores principales: Betti, Michael J., Aldrich, Melinda C., Gamazon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312628/
https://www.ncbi.nlm.nih.gov/pubmed/37398170
http://dx.doi.org/10.1101/2023.06.11.544507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312628/
https://www.ncbi.nlm.nih.gov/pubmed/37398170
http://dx.doi.org/10.1101/2023.06.11.544507

Ejemplares similares