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Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease loci
We introduce CoRE-BED, a framework trained using 19 epigenomic features encompassing 33 major cell and tissue types to predict cell-type-specific regulatory function. CoRE-BED’s interpretability facilitates causal inference and functional prioritization. CoRE-BED identifies nine functional classes d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312628/ https://www.ncbi.nlm.nih.gov/pubmed/37398170 http://dx.doi.org/10.1101/2023.06.11.544507 |