A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor

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The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks that include fatalities. Many SCRAs exhibit much higher efficacy and potency, compared with the phytocannabinoid Δ(9)-tetrahydrocannabinol (THC), at the cann...

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Detalles Bibliográficos
Autores principales: Yano, Hideaki, Chitsazi, Rezvan, Lucaj, Christopher, Tran, Phuong, Hoffman, Alexander F., Baumann, Michael H., Lupica, Carl R., Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312643/
https://www.ncbi.nlm.nih.gov/pubmed/37398099
http://dx.doi.org/10.1101/2023.06.10.544442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312643/
https://www.ncbi.nlm.nih.gov/pubmed/37398099
http://dx.doi.org/10.1101/2023.06.10.544442

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