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A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor
The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks that include fatalities. Many SCRAs exhibit much higher efficacy and potency, compared with the phytocannabinoid Δ(9)-tetrahydrocannabinol (THC), at the cann...
Autores principales: | Yano, Hideaki, Chitsazi, Rezvan, Lucaj, Christopher, Tran, Phuong, Hoffman, Alexander F., Baumann, Michael H., Lupica, Carl R., Shi, Lei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312643/ https://www.ncbi.nlm.nih.gov/pubmed/37398099 http://dx.doi.org/10.1101/2023.06.10.544442 |
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