Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing

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During origin licensing, the eukaryotic replicative helicase Mcm2-7 forms head-to-head double hexamers to prime origins for bidirectional replication. Recent single-molecule and structural studies revealed that one molecule of the helicase loader ORC can sequentially load two Mcm2-7 hexamers to ensu...

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Detalles Bibliográficos
Autores principales: Zhang, Annie, Friedman, Larry J., Gelles, Jeff, Bell, Stephen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312730/
https://www.ncbi.nlm.nih.gov/pubmed/37398123
http://dx.doi.org/10.1101/2023.06.16.545300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312730/
https://www.ncbi.nlm.nih.gov/pubmed/37398123
http://dx.doi.org/10.1101/2023.06.16.545300

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