Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication forks, DNA repair foci, ssRNA, and telomeres. The above functions require...

Descripción completa

Detalles Bibliográficos
Autores principales: Orris, Benjamin, Sung, Min Woo, Bhat, Shridhar, Xu, Yingrong, Huynh, Kevin W., Han, Seungil, Johnson, Darren C., Bosbach, Benedikt, Shields, David J., Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312740/
https://www.ncbi.nlm.nih.gov/pubmed/37398126
http://dx.doi.org/10.1101/2023.06.15.544806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312740/
https://www.ncbi.nlm.nih.gov/pubmed/37398126
http://dx.doi.org/10.1101/2023.06.15.544806

Ejemplares similares