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Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication forks, DNA repair foci, ssRNA, and telomeres. The above functions require...

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Detalles Bibliográficos
Autores principales:	Orris, Benjamin, Sung, Min Woo, Bhat, Shridhar, Xu, Yingrong, Huynh, Kevin W., Han, Seungil, Johnson, Darren C., Bosbach, Benedikt, Shields, David J., Stivers, James T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312740/ https://www.ncbi.nlm.nih.gov/pubmed/37398126 http://dx.doi.org/10.1101/2023.06.15.544806

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