BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias

ITM2B/BRI2 mutations cause familial forms of Alzheimer’s disease (AD)-related dementias by disrupting BRI2’s protein function and leading to the accumulation of amyloidogenic peptides. Although typically studied in neurons, our findings show that BRI2 is highly expressed in microglia, which are cruc...

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Detalles Bibliográficos
Autores principales: Yin, Tao, D’Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312752/
https://www.ncbi.nlm.nih.gov/pubmed/37398330
http://dx.doi.org/10.1101/2023.06.14.544924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312752/
https://www.ncbi.nlm.nih.gov/pubmed/37398330
http://dx.doi.org/10.1101/2023.06.14.544924

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