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BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
ITM2B/BRI2 mutations cause familial forms of Alzheimer’s disease (AD)-related dementias by disrupting BRI2’s protein function and leading to the accumulation of amyloidogenic peptides. Although typically studied in neurons, our findings show that BRI2 is highly expressed in microglia, which are cruc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312752/ https://www.ncbi.nlm.nih.gov/pubmed/37398330 http://dx.doi.org/10.1101/2023.06.14.544924 |