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Evolutionary engineering a larger porin using a loop-to-hairpin mechanism

In protein evolution, diversification is generally driven by genetic duplication. The hallmarks of this mechanism are visible in the repeating topology of various proteins. In outer membrane β-barrels, duplication is visible with β-hairpins as the repeating unit of the barrel. In contrast to the ove...

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Detalles Bibliográficos
Autores principales: Dhar, Rik, Bowman, Alexander M., Hatungimana, Brunojoel, Slusky, Joanna SG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312768/
https://www.ncbi.nlm.nih.gov/pubmed/37398247
http://dx.doi.org/10.1101/2023.06.14.544993