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Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we identified a double-stranded RNA (dsRNA) structure residing within the GATA4 uORF that augments uORF translation a...

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Detalles Bibliográficos
Autores principales: Hedaya, Omar M., Subbaiah, Kadiam C. Venkata, Jiang, Feng, Xie, Li Huitong, Wu, Jiangbin, Khor, EngSoon, Zhu, Mingyi, Mathews, David H., Proschel, Chris, Yao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312771/
https://www.ncbi.nlm.nih.gov/pubmed/37397986
http://dx.doi.org/10.1101/2023.06.15.545153