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Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy
Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we identified a double-stranded RNA (dsRNA) structure residing within the GATA4 uORF that augments uORF translation a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312771/ https://www.ncbi.nlm.nih.gov/pubmed/37397986 http://dx.doi.org/10.1101/2023.06.15.545153 |