Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

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Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we identified a double-stranded RNA (dsRNA) structure residing within the GATA4 uORF that augments uORF translation a...

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Detalles Bibliográficos
Autores principales: Hedaya, Omar M., Subbaiah, Kadiam C. Venkata, Jiang, Feng, Xie, Li Huitong, Wu, Jiangbin, Khor, EngSoon, Zhu, Mingyi, Mathews, David H., Proschel, Chris, Yao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312771/
https://www.ncbi.nlm.nih.gov/pubmed/37397986
http://dx.doi.org/10.1101/2023.06.15.545153
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