QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncovering sites of genetic regulation in cis (37,453 mQTLs and 12...

Descripción completa

Detalles Bibliográficos
Autores principales: Advani, Jayshree, Corso-Diaz, Ximena, Kwicklis, Madeline, van Asten, Freekje, Ratnapriya, Rinki, Mehta, Puja, Hamel, Andrew, Mahrotra, Sudeep, Segrè, Ayellet, Kiel, Christina, Strunz, Tobias, Weber, Bernhard, Chew, Emily, Hernandez, Dena, Montezuma, Sandra, Ferrington, Deborah, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312909/
https://www.ncbi.nlm.nih.gov/pubmed/37398472
http://dx.doi.org/10.21203/rs.3.rs-3011096/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312909/
https://www.ncbi.nlm.nih.gov/pubmed/37398472
http://dx.doi.org/10.21203/rs.3.rs-3011096/v1

Ejemplares similares