Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology

Microglia are implicated in aging, neurodegeneration, and Alzheimer’s disease (AD). Traditional, low-plex, imaging methods fall short of capturing in situ cellular states and interactions in the human brain. We utilized Multiplexed Ion Beam Imaging (MIBI) and data-driven analysis to spatially map pr...

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Detalles Bibliográficos
Autores principales: Mrdjen, Dunja, Amouzgar, Meelad, Cannon, Bryan, Liu, Candace, Spence, Angie, McCaffrey, Erin, Bharadwaj, Anusha, Tebaykin, Dmitry, Bukhari, Syed, Hartmann, Felix J., Kagel, Adam, Vijayaragavan, Kausalia, Oliveria, John Paul, Yakabi, Koya, Serrano, Geidy E., Corrada, Maria M., Kawas, Claudia H., Camacho, Christine, Bosse, Marc, Tibshirani, Robert, Beach, Thomas G., Angelo, Michael, Montine, Thomas, Bendall, Sean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312937/
https://www.ncbi.nlm.nih.gov/pubmed/37398389
http://dx.doi.org/10.21203/rs.3.rs-2987263/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312937/
https://www.ncbi.nlm.nih.gov/pubmed/37398389
http://dx.doi.org/10.21203/rs.3.rs-2987263/v1

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