Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy

Acquired resistance to immune checkpoint immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we found that tumors underwent an epithel...

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Detalles Bibliográficos
Autores principales: Kim, Il-Kyu, Diamond, Mark, Yuan, Salina, Kemp, Samantha, Li, Qinglan, Lin, Jeffrey, Li, Jinyang, Norgard, Robert, Thomas, Stacy, Merolle, Maria, Katsuda, Takeshi, Tobias, John, Politi, Katerina, Vonderheide, Robert, Stanger, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312946/
https://www.ncbi.nlm.nih.gov/pubmed/37398248
http://dx.doi.org/10.21203/rs.3.rs-2960521/v1

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