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Tuning Parameters for Polygenic Risk Score Methods Using GWAS Summary Statistics from Training Data
Predicting genetic risks for common diseases may improve their prevention and early treatment. In recent years, various additive-model-based polygenic risk scores (PRS) methods have been proposed to combine the estimated effects of single nucleotide polymorphisms (SNPs) using data collected from gen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312948/ https://www.ncbi.nlm.nih.gov/pubmed/37398263 http://dx.doi.org/10.21203/rs.3.rs-2939390/v1 |