Poria cocos compounds targeting neuropeptide Y1 receptor (Y(1)R) for weight management: A computational ligand- and structure-based study with molecular dynamics simulations identified beta-amyrin acetate as a putative Y(1)R inhibitor

Poria cocos (PC) is a medicinal herb frequently used in weight-loss clinical trials, however the mechanisms by which its compounds target orexigenic receptors including the neuropeptide Y(1) receptor (Y(1)R) remain largely unknown. This study aimed to screen PC compounds for favourable pharmacokinet...

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Detalles Bibliográficos
Autores principales: Wong, Ann Rann, Hung, Andrew, Yang, Angela Wei Hong, Gill, Harsharn, Lenon, George Binh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313034/
https://www.ncbi.nlm.nih.gov/pubmed/37390097
http://dx.doi.org/10.1371/journal.pone.0277873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313034/
https://www.ncbi.nlm.nih.gov/pubmed/37390097
http://dx.doi.org/10.1371/journal.pone.0277873

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