Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine

BACKGROUND: HNF1A is an essential component of the transcription factor network that controls pancreatic β-cell differentiation, maintenance, and glucose stimulated insulin secretion (GSIS). A continuum of protein malfunction is caused by variations in the HNF1A gene, from severe loss-of-function (L...

Descripción completa

Detalles Bibliográficos
Autores principales: Kavitha, Babu, Ranganathan, Sampathkumar, Gopi, Sundaramoorthy, Vetrivel, Umashankar, Hemavathy, Nagarajan, Mohan, Viswanathan, Radha, Venkatesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313120/
https://www.ncbi.nlm.nih.gov/pubmed/37396188
http://dx.doi.org/10.3389/fendo.2023.1177268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313120/
https://www.ncbi.nlm.nih.gov/pubmed/37396188
http://dx.doi.org/10.3389/fendo.2023.1177268

Ejemplares similares