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Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine
BACKGROUND: HNF1A is an essential component of the transcription factor network that controls pancreatic β-cell differentiation, maintenance, and glucose stimulated insulin secretion (GSIS). A continuum of protein malfunction is caused by variations in the HNF1A gene, from severe loss-of-function (L...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313120/ https://www.ncbi.nlm.nih.gov/pubmed/37396188 http://dx.doi.org/10.3389/fendo.2023.1177268 |