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Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in synaptic plasticity. It is a dodecameric serine/threonine kinase that has been highly conserved across metazoans for over a million years. Despite the extensive knowledge of the mechanisms underlying CaMKII activation, it...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313165/ https://www.ncbi.nlm.nih.gov/pubmed/37390213 http://dx.doi.org/10.1126/sciadv.adh1069 |