Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion

Non-expandable lung (NEL) often occurs during pleural fluid drainage in patients with malignant pleural effusion (MPE). However, data regarding the predictors and prognostic impact of NEL on primary lung cancer patients with MPE receiving pleural fluid drainage, compared to malignant pleural mesothe...

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Autores principales: Kim, Chang Ho, Park, Ji Eun, Cha, Jung Guen, Park, Jongmin, Choi, Sun Ha, Seo, Hyewon, Yoo, Seung Soo, Lee, Shin Yup, Cha, Seung Ick, Park, Jae Yong, Lim, Jae Kwang, Lee, Jaehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313309/
https://www.ncbi.nlm.nih.gov/pubmed/37390258
http://dx.doi.org/10.1097/MD.0000000000034134
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author Kim, Chang Ho
Park, Ji Eun
Cha, Jung Guen
Park, Jongmin
Choi, Sun Ha
Seo, Hyewon
Yoo, Seung Soo
Lee, Shin Yup
Cha, Seung Ick
Park, Jae Yong
Lim, Jae Kwang
Lee, Jaehee
author_facet Kim, Chang Ho
Park, Ji Eun
Cha, Jung Guen
Park, Jongmin
Choi, Sun Ha
Seo, Hyewon
Yoo, Seung Soo
Lee, Shin Yup
Cha, Seung Ick
Park, Jae Yong
Lim, Jae Kwang
Lee, Jaehee
author_sort Kim, Chang Ho
collection PubMed
description Non-expandable lung (NEL) often occurs during pleural fluid drainage in patients with malignant pleural effusion (MPE). However, data regarding the predictors and prognostic impact of NEL on primary lung cancer patients with MPE receiving pleural fluid drainage, compared to malignant pleural mesothelioma (MPM), are limited. This study was aimed to investigate the clinical characteristics of lung cancer patients with MPE developing NEL following ultrasonography (USG)-guided percutaneous catheter drainage (PCD) and compare the clinical outcomes between those with and without NEL. Clinical, laboratory, pleural fluid, and radiologic data and survival outcomes of lung cancer patients with MPE undergoing USG-guided PCD were retrospectively reviewed and compared between those with and without NEL. Among 121 primary lung cancer patients with MPE undergoing PCD, NEL occurred in 25 (21%). Higher pleural fluid lactate dehydrogenase (LDH) levels and presence of endobronchial lesions were associated with development of NEL. The median time to catheter removal was significantly extended in those with NEL compared to those without (P = .014). NEL was significantly associated with poor survival outcome in lung cancer patients with MPE undergoing PCD, along with poor Eastern Cooperative Oncology Group (ECOG) performance status (PS), the presence of distant metastasis, higher serum C-reactive protein (CRP) levels, and not receiving chemotherapy. NEL developed in one-fifth of lung cancer patients undergoing PCD for MPE and was associated with high pleural fluid LDH levels and the presence of endobronchial lesions. NEL may negatively affect overall survival in lung cancer patients with MPE receiving PCD.
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spelling pubmed-103133092023-07-01 Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion Kim, Chang Ho Park, Ji Eun Cha, Jung Guen Park, Jongmin Choi, Sun Ha Seo, Hyewon Yoo, Seung Soo Lee, Shin Yup Cha, Seung Ick Park, Jae Yong Lim, Jae Kwang Lee, Jaehee Medicine (Baltimore) 6700 Non-expandable lung (NEL) often occurs during pleural fluid drainage in patients with malignant pleural effusion (MPE). However, data regarding the predictors and prognostic impact of NEL on primary lung cancer patients with MPE receiving pleural fluid drainage, compared to malignant pleural mesothelioma (MPM), are limited. This study was aimed to investigate the clinical characteristics of lung cancer patients with MPE developing NEL following ultrasonography (USG)-guided percutaneous catheter drainage (PCD) and compare the clinical outcomes between those with and without NEL. Clinical, laboratory, pleural fluid, and radiologic data and survival outcomes of lung cancer patients with MPE undergoing USG-guided PCD were retrospectively reviewed and compared between those with and without NEL. Among 121 primary lung cancer patients with MPE undergoing PCD, NEL occurred in 25 (21%). Higher pleural fluid lactate dehydrogenase (LDH) levels and presence of endobronchial lesions were associated with development of NEL. The median time to catheter removal was significantly extended in those with NEL compared to those without (P = .014). NEL was significantly associated with poor survival outcome in lung cancer patients with MPE undergoing PCD, along with poor Eastern Cooperative Oncology Group (ECOG) performance status (PS), the presence of distant metastasis, higher serum C-reactive protein (CRP) levels, and not receiving chemotherapy. NEL developed in one-fifth of lung cancer patients undergoing PCD for MPE and was associated with high pleural fluid LDH levels and the presence of endobronchial lesions. NEL may negatively affect overall survival in lung cancer patients with MPE receiving PCD. Lippincott Williams & Wilkins 2023-06-30 /pmc/articles/PMC10313309/ /pubmed/37390258 http://dx.doi.org/10.1097/MD.0000000000034134 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 6700
Kim, Chang Ho
Park, Ji Eun
Cha, Jung Guen
Park, Jongmin
Choi, Sun Ha
Seo, Hyewon
Yoo, Seung Soo
Lee, Shin Yup
Cha, Seung Ick
Park, Jae Yong
Lim, Jae Kwang
Lee, Jaehee
Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title_full Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title_fullStr Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title_full_unstemmed Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title_short Clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
title_sort clinical predictors and outcomes of non-expandable lung following percutaneous catheter drainage in lung cancer patients with malignant pleural effusion
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313309/
https://www.ncbi.nlm.nih.gov/pubmed/37390258
http://dx.doi.org/10.1097/MD.0000000000034134
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