Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfer...

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Detalles Bibliográficos
Autores principales: Gou, Dongmei, Liu, Rui, Shan, Xiaoqun, Deng, Haijun, Chen, Chang, Xiang, Jin, Liu, Yi, Gao, Qingzhu, Li, Zhi, Huang, Ailong, Wang, Kai, Tang, Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313362/
https://www.ncbi.nlm.nih.gov/pubmed/37166978
http://dx.doi.org/10.1172/JCI161713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313362/
https://www.ncbi.nlm.nih.gov/pubmed/37166978
http://dx.doi.org/10.1172/JCI161713

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