Host genetic background is a barrier to broadly effective vaccine–mediated protection against tuberculosis

Heterogeneity in human immune responses is difficult to model in standard laboratory mice. To understand how host variation affects Bacillus Calmette Guerin–induced (BCG-induced) immunity against Mycobacterium tuberculosis, we studied 24 unique collaborative cross (CC) mouse strains, which differ pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Rocky, Gong, Diana N., Williams, Travis, Ogunsola, Abiola F., Cavallo, Kelly, Lindestam Arlehamn, Cecilia S., Acolatse, Sarah, Beamer, Gillian L., Ferris, Martin T., Sassetti, Christopher M., Lauffenburger, Douglas A., Behar, Samuel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313364/
https://www.ncbi.nlm.nih.gov/pubmed/37200108
http://dx.doi.org/10.1172/JCI167762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313364/
https://www.ncbi.nlm.nih.gov/pubmed/37200108
http://dx.doi.org/10.1172/JCI167762

Ejemplares similares