Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the eyes of people with diabetes despite treatment with...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Sharma, Deepti, Dinabandhu, Aumreetam, Sanchez, Jaron, Applewhite, Brooks, Jee, Kathleen, Deshpande, Monika, Flores-Bellver, Miguel, Hu, Ming-Wen, Guo, Chuanyu, Salman, Shaima, Hwang, Yousang, Anders, Nicole M., Rudek, Michelle A., Qian, Jiang, Canto-Soler, M. Valeria, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313368/
https://www.ncbi.nlm.nih.gov/pubmed/37227777
http://dx.doi.org/10.1172/JCI163290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313368/
https://www.ncbi.nlm.nih.gov/pubmed/37227777
http://dx.doi.org/10.1172/JCI163290

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