Cargando…

Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the eyes of people with diabetes despite treatment with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jing, Sharma, Deepti, Dinabandhu, Aumreetam, Sanchez, Jaron, Applewhite, Brooks, Jee, Kathleen, Deshpande, Monika, Flores-Bellver, Miguel, Hu, Ming-Wen, Guo, Chuanyu, Salman, Shaima, Hwang, Yousang, Anders, Nicole M., Rudek, Michelle A., Qian, Jiang, Canto-Soler, M. Valeria, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313368/ https://www.ncbi.nlm.nih.gov/pubmed/37227777 http://dx.doi.org/10.1172/JCI163290

Ejemplares similares

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization
por: Qin, Yu, et al.
Publicado: (2022)

HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy
por: Salman, Shaima, et al.
Publicado: (2022)

Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy
por: Jee, Kathleen, et al.
Publicado: (2017)

Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes
por: Applewhite, Brooks P., et al.
Publicado: (2017)

Aqueous proteins help predict the response of patients with neovascular age-related macular degeneration to anti-VEGF therapy
por: Cao, Xuan, et al.
Publicado: (2022)

HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
por: Guo, Chuanyu, et al.
Publicado: (2023)

Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy
por: Rodrigues, Murilo, et al.
Publicado: (2016)

PAI-1 is a vascular cell–specific HIF-2–dependent angiogenic factor that promotes retinal neovascularization in diabetic patients
por: Qin, Yaowu, et al.
Publicado: (2022)

Aflibercept more effectively weans patients with neovascular age-related macular degeneration off therapy compared with bevacizumab
por: Cao, Xuan, et al.
Publicado: (2023)

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia
por: Meng, Qianli, et al.
Publicado: (2017)

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma
por: Hu, Ke, et al.
Publicado: (2016)

Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma
por: Hu, Ke, et al.
Publicado: (2021)

Factors Associated With a Patient’s Decision to Select a Cost-effective vs the Most Effective Therapy for Their Own Eye Disease
por: Malik, Danyal, et al.
Publicado: (2021)

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
por: Babapoor-Farrokhran, Savalan, et al.
Publicado: (2015)

VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy
por: Rodrigues, Murilo, et al.
Publicado: (2013)

Upregulation of angiopoietin-like 4 by viral G protein-coupled receptor promotes angiogenesis and vascular permeability in Kaposi’s sarcoma
por: Ma, Tao, et al.
Publicado: (2010)

Stem Cell Sources and Their Potential for the Treatment of Retinal Degenerations
por: Canto-Soler, Valeria, et al.
Publicado: (2016)

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma
por: Jham, Bruno C., et al.
Publicado: (2011)

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization
por: Wang, Yufeng, et al.
Publicado: (2021)

Overexpression of CDSP32 (GhTRX134) Cotton Gene Enhances Drought, Salt, and Oxidative Stress Tolerance in Arabidopsis
por: Elasad, Mohammed, et al.
Publicado: (2020)

Oxygen-regulated transcription factors and their role in pulmonary disease
por: Semenza, Gregg L
Publicado: (2000)

Beam allocation for S134
por: CERN. Geneva. Electronic Experiments Committee
Publicado: (1973)

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
por: Luo, Weibo, et al.
Publicado: (2011)

Maintenance of redox homeostasis by hypoxia-inducible factors
por: Samanta, Debangshu, et al.
Publicado: (2017)

On either side of homeostasis: EPAS1 gain- and loss-of-function mutations
por: Prchal, Josef T., et al.
Publicado: (2023)

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis
por: Cao, Liwei, et al.
Publicado: (2022)

Hypoxia-inducible factors: cancer progression and clinical translation
por: Wicks, Elizabeth E., et al.
Publicado: (2022)

134th SPSC Meeting
Publicado: (2019)

134th LHCC Meeting
Publicado: (2018)

Subject index for volume 134
Publicado: (1984)

Level structure of odd-odd $^{134}$Sb populated in the $\beta\!^{-}$-decays of $^{134, 135}$Sn
por: Shergur, J, et al.
Publicado: (2005)

The Role of the Immune Response in Age-Related Macular Degeneration
por: Whitcup, Scott M., et al.
Publicado: (2013)

A Surgical Kit for Stem Cell-Derived Retinal Pigment Epithelium Transplants: Collection, Transportation, and Subretinal Delivery
por: Li, Kang V., et al.
Publicado: (2022)

NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification
por: Yang, Yongkang, et al.
Publicado: (2022)

Synthesis of Novel 1,3,4-Oxadiazole-Derived α-Aminophosphonates/α-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian Coronavirus Infectious Bronchitis Virus
por: Hkiri, Shaima, et al.
Publicado: (2022)

Minutes of the 134th Meeting of the LHCC
por: CERN. Geneva. The LHC experiments Committee
Publicado: (2018)

134: THE EFFECTIVENESS OF CXL IN THE TREATMENT OF KERATOCONUS
por: Esmaeilnezhad, Mahdieh, et al.
Publicado: (2017)

SUBJECT INDEX: VOLUME 134, 2003
Publicado: (2003)

Health Tract, No. 134: Poisons and Antidotes
Publicado: (1863)

Health Tract, No. 134: Poisons and Antidotes
Publicado: (1865)

Cannot write session to /tmp/vufind_sessions/sess_5g09guhjgl3j8a5ij1djc6pc7t