Structure and transport mechanism of the human calcium pump SPCA1

Secretory-pathway Ca(2+)-ATPases (SPCAs) play critical roles in maintaining Ca(2+) homeostasis, but the exact mechanism of SPCAs-mediated Ca(2+) transport remains unclear. Here, we determined six cryo-electron microscopy (cryo-EM) structures of human SPCA1 (hSPCA1) in a series of intermediate states...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Mengqi, Wu, Cang, Song, Tiefeng, Pan, Kewu, Wang, Yong, Liu, Zhongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313705/
https://www.ncbi.nlm.nih.gov/pubmed/37258749
http://dx.doi.org/10.1038/s41422-023-00827-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313705/
https://www.ncbi.nlm.nih.gov/pubmed/37258749
http://dx.doi.org/10.1038/s41422-023-00827-x

Ejemplares similares