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Structure and transport mechanism of the human calcium pump SPCA1

Secretory-pathway Ca(2+)-ATPases (SPCAs) play critical roles in maintaining Ca(2+) homeostasis, but the exact mechanism of SPCAs-mediated Ca(2+) transport remains unclear. Here, we determined six cryo-electron microscopy (cryo-EM) structures of human SPCA1 (hSPCA1) in a series of intermediate states...

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Detalles Bibliográficos
Autores principales:	Wu, Mengqi, Wu, Cang, Song, Tiefeng, Pan, Kewu, Wang, Yong, Liu, Zhongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313705/ https://www.ncbi.nlm.nih.gov/pubmed/37258749 http://dx.doi.org/10.1038/s41422-023-00827-x

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