Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity

DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase—stimulator of interferon genes) pathway in antigen-presenting cells (APCs) and promote antitumor immunity. However, conven...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chaoyu, Zhang, Ruoshi, He, Jia, Yu, Lvshan, Li, Xinyan, Zhang, Junxia, Li, Sai, Zhang, Conggang, Kagan, Jonathan C., Karp, Jeffrey M., Kuai, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313815/
https://www.ncbi.nlm.nih.gov/pubmed/37391428
http://dx.doi.org/10.1038/s41467-023-39607-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313815/
https://www.ncbi.nlm.nih.gov/pubmed/37391428
http://dx.doi.org/10.1038/s41467-023-39607-x

Ejemplares similares