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Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes

Strenuous physical exercise causes a massive elevation in the concentration of circulating cell-free DNA (cfDNA), which correlates with effort intensity and duration. The cellular sources and physiological drivers of this phenomenon are unknown. Using methylation patterns of cfDNA and associated his...

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Detalles Bibliográficos
Autores principales: Fridlich, Ori, Peretz, Ayelet, Fox-Fisher, Ilana, Pyanzin, Sheina, Dadon, Ziv, Shcolnik, Eilon, Sadeh, Ronen, Fialkoff, Gavriel, Sharkia, Israa, Moss, Joshua, Arpinati, Ludovica, Nice, Shachar, Nogiec, Christopher D., Ahuno, Samuel Terkper, Li, Rui, Taborda, Eddie, Dunkelbarger, Sonia, Fridlender, Zvi G., Polak, Paz, Kaplan, Tommy, Friedman, Nir, Glaser, Benjamin, Shemer, Ruth, Constantini, Naama, Dor, Yuval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313937/
https://www.ncbi.nlm.nih.gov/pubmed/37290439
http://dx.doi.org/10.1016/j.xcrm.2023.101074