A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis

OBJECTIVES: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular model of transmitochondrial cybrids. METHODS: Three prospective cohorts contributed particip...

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Detalles Bibliográficos
Autores principales: Durán-Sotuela, Alejandro, Fernandez-Moreno, Mercedes, Suárez-Ulloa, Victoria, Vázquez-García, Jorge, Relaño, Sara, Hermida-Gómez, Tamara, Balboa-Barreiro, Vanesa, Lourido-Salas, Lucia, Calamia, Valentina, Fernandez-Puente, Patricia, Ruiz-Romero, Cristina, Fernández-Tajes, Juan, Vaamonde-García, Carlos, de Andrés, María C, Oreiro, Natividad, Blanco, Francisco J, Rego-Perez, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313990/
https://www.ncbi.nlm.nih.gov/pubmed/37024296
http://dx.doi.org/10.1136/ard-2022-223570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313990/
https://www.ncbi.nlm.nih.gov/pubmed/37024296
http://dx.doi.org/10.1136/ard-2022-223570

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