G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans

BACKGROUND: Recombinant granulocyte colony-stimulating factor (G-CSF) is routinely administered for prophylaxis or treatment of chemotherapy-induced neutropenia. Chronic myelopoiesis and granulopoiesis in patients with cancer has been shown to induce immature monocytes and neutrophils that contribut...

Descripción completa

Detalles Bibliográficos
Autores principales: Cardot-Ruffino, Victoire, Bollenrucher, Naima, Delius, Luisa, Wang, S Jennifer, Brais, Lauren K, Remland, Joshua, Keheler, C Elizabeth, Sullivan, Keri M, Abrams, Thomas A, Biller, Leah H, Enzinger, Peter C, McCleary, Nadine J, Patel, Anuj K, Rubinson, Douglas A, Schlechter, Benjamin, Slater, Sarah, Yurgelun, Matthew B, Cleary, James M, Perez, Kimberly, Dougan, Michael, Ng, Kimmie, Wolpin, Brian M, Singh, Harshabad, Dougan, Stephanie K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314699/
https://www.ncbi.nlm.nih.gov/pubmed/37344102
http://dx.doi.org/10.1136/jitc-2022-006589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314699/
https://www.ncbi.nlm.nih.gov/pubmed/37344102
http://dx.doi.org/10.1136/jitc-2022-006589

Ejemplares similares