Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1

Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease – yielding many hits but only few identified c...

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Detalles Bibliográficos
Autores principales: Bagka, Meropi, Choi, Hyeonyi, Héritier, Margaux, Schwaemmle, Hanna, Pasquer, Quentin T. L., Braun, Simon M. G., Scapozza, Leonardo, Wu, Yibo, Hoogendoorn, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314895/
https://www.ncbi.nlm.nih.gov/pubmed/37393376
http://dx.doi.org/10.1038/s41467-023-39657-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314895/
https://www.ncbi.nlm.nih.gov/pubmed/37393376
http://dx.doi.org/10.1038/s41467-023-39657-1

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