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Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease – yielding many hits but only few identified c...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314895/ https://www.ncbi.nlm.nih.gov/pubmed/37393376 http://dx.doi.org/10.1038/s41467-023-39657-1 |