Eltrombopag directly activates BAK and induces apoptosis

Small molecule direct BAK activators can potentially be used for the development of anti-cancer drugs or as tools to study BAK activation. The thrombopoietin receptor agonist eltrombopag (Eltro) inhibits BAX activation and BAX-mediated apoptosis. Here we report that, in contrast to its function as a...

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Detalles Bibliográficos
Autores principales: Chen, Meng, Hu, Lei, Bao, Xuyuan, Ye, Kaiqin, Li, Yunjian, Zhang, Zhiyong, Kaufmann, Scott H., Xiao, Jun, Dai, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314921/
https://www.ncbi.nlm.nih.gov/pubmed/37393297
http://dx.doi.org/10.1038/s41419-023-05918-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314921/
https://www.ncbi.nlm.nih.gov/pubmed/37393297
http://dx.doi.org/10.1038/s41419-023-05918-6

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