Cargando…
Regulation of Macrophage Cell Surface GAPDH Alters LL-37 Internalization and Downstream Effects in the Cell
Mycobacterium tuberculosis (M.tb), the major causative agent of tuberculosis, has evolved mechanisms to evade host defenses and persist within host cells. Host-directed therapies against infected cells are emerging as an effective option. Cationic host defense peptide LL-37 is known to internalize i...
Autores principales: | Dhiman, Asmita, Talukdar, Sharmila, Chaubey, Gaurav Kumar, Dilawari, Rahul, Modanwal, Radheshyam, Chaudhary, Surbhi, Patidar, Anil, Boradia, Vishant Mahendra, Kumbhar, Pradeep, Raje, Chaaya Iyengar, Raje, Manoj |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315065/ https://www.ncbi.nlm.nih.gov/pubmed/37080180 http://dx.doi.org/10.1159/000530083 |
Ejemplares similares
-
Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells
por: Chaudhary, Surbhi, et al.
Publicado: (2021) -
Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin
por: Malhotra, Himanshu, et al.
Publicado: (2017) -
Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv
por: Boradia, Vishant Mahendra, et al.
Publicado: (2016) -
Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway
por: Chauhan, Anoop S., et al.
Publicado: (2015) -
The Mycobacterium tuberculosis PE15/PPE20 complex transports calcium across the outer membrane
por: Boradia, Vishant, et al.
Publicado: (2022)