Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure

INTRODUCTION: Medulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which is accompanied by severe side effects, raising the need for innovative therapies. Disruption of the microcephaly-related gene Citron ki...

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Detalles Bibliográficos
Autores principales: Pallavicini, Gianmarco, Iegiani, Giorgia, Parolisi, Roberta, Ferraro, Alessia, Garello, Francesca, Bitonto, Valeria, Terreno, Enzo, Gai, Marta, Di Cunto, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315473/
https://www.ncbi.nlm.nih.gov/pubmed/37404750
http://dx.doi.org/10.3389/fonc.2023.1202585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315473/
https://www.ncbi.nlm.nih.gov/pubmed/37404750
http://dx.doi.org/10.3389/fonc.2023.1202585

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