Characterization of 405B8H3(D‐E), a newly engineered high affinity chimeric LAG‐3 antibody with potent antitumor activity

Lymphocyte activation gene‐3 (LAG‐3) is a type I transmembrane protein with structural similarities to CD4. Overexpression of LAG‐3 enables cancer cells to escape immune surveillance, while its blockade reinvigorates exhausted T cells and strengthens anti‐infection immunity. Blockade of LAG‐3 may ha...

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Detalles Bibliográficos
Autores principales: Lan, Xiaoxuan, Yang, Teddy Tat Chi, Wang, Yinghui, Qu, Baoyuan, Rong, Shaofeng, Song, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315732/
https://www.ncbi.nlm.nih.gov/pubmed/37302810
http://dx.doi.org/10.1002/2211-5463.13648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315732/
https://www.ncbi.nlm.nih.gov/pubmed/37302810
http://dx.doi.org/10.1002/2211-5463.13648

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