Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1

Secondary structures formed by expanded CUG RNA are involved in the pathobiology of myotonic dystrophy type 1. Understanding the molecular basis of toxic RNA structures can provide insights into the mechanism of disease pathogenesis and accelerate the drug discovery process. Here, we report the crys...

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Detalles Bibliográficos
Autores principales: Wang, Shun-Ching, Chen, Yi-Tsao, Satange, Roshan, Chu, Jhih-Wei, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316006/
https://www.ncbi.nlm.nih.gov/pubmed/37245780
http://dx.doi.org/10.1016/j.jbc.2023.104864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316006/
https://www.ncbi.nlm.nih.gov/pubmed/37245780
http://dx.doi.org/10.1016/j.jbc.2023.104864

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