Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells

Cells need to coordinate nutrient availability with their growth and proliferation. In eukaryotic cells, this coordination is mediated by the mechanistic target of the rapamycin complex 1 (mTORC1) pathway. mTORC1 activation is regulated by two GTPase units, the Rag GTPase heterodimer and the Rheb GT...

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Detalles Bibliográficos
Autores principales: Doxsey, Dylan D., Tettoni, Steven D., Egri, Shawn B., Shen, Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316081/
https://www.ncbi.nlm.nih.gov/pubmed/37269949
http://dx.doi.org/10.1016/j.jbc.2023.104880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316081/
https://www.ncbi.nlm.nih.gov/pubmed/37269949
http://dx.doi.org/10.1016/j.jbc.2023.104880

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