Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes

[Image: see text] Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two different heteroatom motifs across an olefin backbone, thus streamlining the access to α-aminoboronic acid derivatives from simple precursors. The method...

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Autores principales: Talavera, Laura, Freund, Robert R. A., Zhang, Huihui, Wakeling, Matthew, Jensen, Mara, Martin, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316398/
https://www.ncbi.nlm.nih.gov/pubmed/37404837
http://dx.doi.org/10.1021/acscatal.3c00888
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author Talavera, Laura
Freund, Robert R. A.
Zhang, Huihui
Wakeling, Matthew
Jensen, Mara
Martin, Ruben
author_facet Talavera, Laura
Freund, Robert R. A.
Zhang, Huihui
Wakeling, Matthew
Jensen, Mara
Martin, Ruben
author_sort Talavera, Laura
collection PubMed
description [Image: see text] Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two different heteroatom motifs across an olefin backbone, thus streamlining the access to α-aminoboronic acid derivatives from simple precursors. The method is characterized by its simplicity and generality across a wide number of coupling counterparts.
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spelling pubmed-103163982023-07-04 Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes Talavera, Laura Freund, Robert R. A. Zhang, Huihui Wakeling, Matthew Jensen, Mara Martin, Ruben ACS Catal [Image: see text] Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two different heteroatom motifs across an olefin backbone, thus streamlining the access to α-aminoboronic acid derivatives from simple precursors. The method is characterized by its simplicity and generality across a wide number of coupling counterparts. American Chemical Society 2023-04-10 /pmc/articles/PMC10316398/ /pubmed/37404837 http://dx.doi.org/10.1021/acscatal.3c00888 Text en © 2023 American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Talavera, Laura
Freund, Robert R. A.
Zhang, Huihui
Wakeling, Matthew
Jensen, Mara
Martin, Ruben
Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title_full Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title_fullStr Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title_full_unstemmed Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title_short Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes
title_sort nickel-catalyzed 1,1-aminoborylation of unactivated terminal alkenes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316398/
https://www.ncbi.nlm.nih.gov/pubmed/37404837
http://dx.doi.org/10.1021/acscatal.3c00888
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