Deep neural networks with knockoff features identify nonlinear causal relations and estimate effect sizes in complex biological systems

BACKGROUND: Learning the causal structure helps identify risk factors, disease mechanisms, and candidate therapeutics for complex diseases. However, although complex biological systems are characterized by nonlinear associations, existing bioinformatic methods of causal inference cannot identify the...

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Detalles Bibliográficos
Autores principales: Fan, Zhenjiang, Kernan, Kate F, Sriram, Aditya, Benos, Panayiotis V, Canna, Scott W, Carcillo, Joseph A, Kim, Soyeon, Park, Hyun Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316696/
https://www.ncbi.nlm.nih.gov/pubmed/37395630
http://dx.doi.org/10.1093/gigascience/giad044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316696/
https://www.ncbi.nlm.nih.gov/pubmed/37395630
http://dx.doi.org/10.1093/gigascience/giad044

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