MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1α/GYS1/UDPG/P2Y(14) pathway

BACKGROUND: Nonresolving inflammation is a major driver of disease and needs to be taken seriously. Hypoxia-inducible factor (HIF) is closely associated with inflammation. Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs), as stabilizers of HIF, have recently been reported to have th...

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Detalles Bibliográficos
Autores principales: Qian, Lingling, Chen, Xiao-qin, Kong, Deyang, Wang, Gaoyuan, Cao, Yun, Xiao, Yingchun, Cao, Jing-yuan, Zou, Chunbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317019/
https://www.ncbi.nlm.nih.gov/pubmed/37404479
http://dx.doi.org/10.7717/peerj.15591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317019/
https://www.ncbi.nlm.nih.gov/pubmed/37404479
http://dx.doi.org/10.7717/peerj.15591

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