Dysregulated metabolism of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production

Herpes simplex virus 1 (HSV1) expresses its genes in a classical cascade culminating in the production of large amounts of structural proteins to facilitate virus assembly. HSV1 lacking the virus protein VP22 (Δ22) exhibits late translational shutoff, a phenotype that has been attributed to the unre...

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Detalles Bibliográficos
Autores principales: Pheasant, Kathleen, Perry, Dana, Wise, Emma L., Cheng, Vivian, Elliott, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317221/
https://www.ncbi.nlm.nih.gov/pubmed/37343008
http://dx.doi.org/10.1371/journal.ppat.1010966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317221/
https://www.ncbi.nlm.nih.gov/pubmed/37343008
http://dx.doi.org/10.1371/journal.ppat.1010966

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