Cargando…

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels

Hyperpolarized-activated and cyclic nucleotide-gated (HCN) channels are the only members of the voltage-gated ion channel superfamily in mammals that open upon hyperpolarization, conferring them pacemaker properties that are instrumental for rhythmic firing of cardiac and neuronal cells. Activation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elbahnsi, Ahmad, Cowgill, John, Burtscher, Verena, Wedemann, Linda, Zeckey, Luise, Chanda, Baron, Delemotte, Lucie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317503/ https://www.ncbi.nlm.nih.gov/pubmed/37341381 http://dx.doi.org/10.7554/eLife.80303

Ejemplares similares

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
por: Kasimova, Marina A, et al.
Publicado: (2019)

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
por: Hou, Panpan, et al.
Publicado: (2019)

Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling
por: Fleetwood, Oliver, et al.
Publicado: (2021)

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
por: Porro, Alessandro, et al.
Publicado: (2019)

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel
por: Burtscher, Verena, et al.
Publicado: (2023)

Identification of electroporation sites in the complex lipid organization of the plasma membrane
por: Rems, Lea, et al.
Publicado: (2022)

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides
por: DeBerg, Hannah A., et al.
Publicado: (2016)

Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning
por: Mitrovic, Darko, et al.
Publicado: (2023)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels
por: Goldschen-Ohm, Marcel P, et al.
Publicado: (2016)

A label-free approach to detect ligand binding to cell surface proteins in real time
por: Burtscher, Verena, et al.
Publicado: (2018)

Mapping Electromechanical Coupling Pathways in Voltage-Gated Ion Channels: Challenges and the Way Forward
por: Cowgill, John, et al.
Publicado: (2021)

Activation of the archaeal ion channel MthK is exquisitely regulated by temperature
por: Jiang, Yihao, et al.
Publicado: (2020)

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K(+) channel
por: Fernández-Mariño, Ana I., et al.
Publicado: (2018)

Top-down machine learning approach for high-throughput single-molecule analysis
por: White, David S, et al.
Publicado: (2020)

Effect of helical kink in antimicrobial peptides on membrane pore formation
por: Tuerkova, Alzbeta, et al.
Publicado: (2020)

Sublytic gasdermin-D pores captured in atomistic molecular simulations
por: Schaefer, Stefan L, et al.
Publicado: (2022)

Investigating molecular crowding within nuclear pores using polarization-PALM
por: Fu, Guo, et al.
Publicado: (2017)

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
por: Strege, Peter R, et al.
Publicado: (2023)

Poring over furrows
por: Fisher, Skylar ID, et al.
Publicado: (2017)

Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics
por: Ananth, Adithya N, et al.
Publicado: (2018)

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore
por: Yeung, Priscilla S-W, et al.
Publicado: (2020)

Ion permeation pathway within the internal pore of P2X receptor channels
por: Tam, Stephanie W, et al.
Publicado: (2023)

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
por: Hidalgo, Frank, et al.
Publicado: (2022)

Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions
por: Sorum, Ben, et al.
Publicado: (2017)

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
por: Zheng, Wang, et al.
Publicado: (2019)

The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells
por: Russell, Charles M, et al.
Publicado: (2022)

Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
por: Lam, Andy KM, et al.
Publicado: (2018)

Dilation of fusion pores by crowding of SNARE proteins
por: Wu, Zhenyong, et al.
Publicado: (2017)

Electromechanical coupling mechanism for activation and inactivation of an HCN channel
por: Dai, Gucan, et al.
Publicado: (2021)

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism
por: Li, Yang, et al.
Publicado: (2017)

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition
por: Karasawa, Akira, et al.
Publicado: (2017)

A critical residue in the α(1)M2–M3 linker regulating mammalian GABA(A) receptor pore gating by diazepam
por: Nors, Joseph W, et al.
Publicado: (2021)

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation
por: Cowgill, John, et al.
Publicado: (2019)

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states
por: Clouser, Amanda F, et al.
Publicado: (2019)

Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding
por: Dayal, Anamika, et al.
Publicado: (2021)

A selectivity filter at the intracellular end of the acid-sensing ion channel pore
por: Lynagh, Timothy, et al.
Publicado: (2017)

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex
por: Vovk, Andrei, et al.
Publicado: (2016)

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
por: Leung, Carl, et al.
Publicado: (2014)

Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner
por: Lowe, Alan R, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_m7c2l4d09tl3utmjdjmvgps1n6