Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Chronic lymphocytic leukaemia (CLL) cells can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear how these differences...

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Detalles Bibliográficos
Autores principales: Bryant, Dean, Smith, Lindsay, Rogers-Broadway, Karly Rai, Karydis, Laura, Woo, Jeongmin, Blunt, Matthew D., Forconi, Francesco, Stevenson, Freda K., Goodnow, Christopher, Russell, Amanda, Humburg, Peter, Packham, Graham, Steele, Andrew J., Strefford, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317834/
https://www.ncbi.nlm.nih.gov/pubmed/37169950
http://dx.doi.org/10.1038/s41375-023-01918-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317834/
https://www.ncbi.nlm.nih.gov/pubmed/37169950
http://dx.doi.org/10.1038/s41375-023-01918-9

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